Zanaflex a muscle relaxant is used to help relax certain muscles in your body. It relieves the spasms and increased muscle tone caused by medical problems such as multiple sclerosis or spinal injury. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
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Tizanidine is an agonist at ?2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways The overall effect of these actions is thought to reduce facilitation of spinal motor neurons The imidazoline chemical structure of tizanidine is related to that of the anti-hypertensive drug clonidine and other ?2-adrenergic agonists.
Tizanidine (brandnames Zanaflex, Sirdalud) is a drug which is used
as a muscle relaxant. It is a centrally acting ?-2 adrenergic agonist.
It is used to treat the spasms, cramping, and tightness of muscles
caused by medical problems such as multiple sclerosis, spastic diplegia,
back pain, or certain other injuries to the spine or central nervous
system. It is also prescribed off-label as a sleep aid, seizure
inhibitor, and for some symptoms of fibromyalgia. Tizanidine may
cause hypotension so caution is advised when it is used in patients
who have a history of orthostatic hypotension. Take Zanaflex as
directed. Your dosage will probably need to be adjusted by your
doctor initially to achieve satisfactory results. Follow directions
exactly.
Nausea, drowsiness, dizziness, constipation, unusual weakness or dry mouth might occur. If these continue or are bothersome, notify your doctor. To minimize dizziness, stand up slowly when arising from a sitting or lying position. Notify your doctor if you develop: yellowing skin or eyes, stomach pain, vomiting, hallucinations. Very unlikely but report: vision or hearing changes, urinary frequency or burning, slow or irregular heartbeat, black stool. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.
A review of the safety surveillance database revealed cases of intentional and accidental tizanidine overdose. Some of the cases resulted in fatality and many of the intentional overdoses were with multiple drugs including CNS depressants. The clinical manifestations of tizanidine overdose were consistent with its known pharmacology. In the majority of cases a decrease in sensorium was observed including lethargy, somnolence, confusion and coma Depressed cardiac function are also observed including most often bradycardia and hypotension. Respiratory depression is another common feature of tizanidine overdose Should overdose occur, basic steps to ensure the adequacy of an airway and the monitoring of cardiovascular and respiratory systems should be undertaken.
Use caution when driving, operating machinery, or performing other hazardous activities. Zanaflex may cause drowsiness and dizziness. If you experience drowsiness or dizziness, avoid these activities. Dizziness is most likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall. Use caution with alcohol, other muscle relaxants, sleep or anxiety medicines, and pain medicines. These drugs may increase drowsiness and dizziness while you are taking Zanaflex.